Jingjing Shen
Staff Scientist
About Jingjing
After receiving her medical degree from Beijing Capital Medical University in 1983, Jingjing took a position as a research assistant professor at the Navy General Hospital in Beijing.
From 1989 to 2000 Jingjing worked in the Immunogenetics Laboratory at the Beijing Institute of Pediatrics and contributed to projects including the WHO DIAMOND Project, an IDDM molecular epidemiology in China, a study of CETP gene mutation in four Chinese populations and an HLA disease association study.
After leaving Chica, she worked for a year as a visiting scholar in the Genetic Epidemiology Unit at the National Public Health Institute in Helsinki, Finland where she studied HLA haplotypes of IDDM patients in different populations.
In late 2001 Jingjing arrived at the University of Chicago and worked for the next 15 years in the Department of Neurosurgery, where she contributed to many different projects probing immunological and neurological systems in mouse and human models.
Finally, in 2017, she joined the Esser-Kahn lab, where she assists with immunoengineering studies in mice.
Education
M.D. Beijing Capital Medical University; Beijing P.R. China; 1983
Favorite Quote
“The only person you can rely on is yourself.”
– Danny Rubin
Scientific Hero
Jonas Edward Salk
If you could be a piece of lab equipment, what would you be?
"Mouse"
Jingjing's Research
Immunology, molecular biology, animal experiments
Lab Publications
Weiss, A. M., Lopez, M. A., Rosenberger, M. G., Kim, J. Y., Shen, J., Chen, Q., … Esser-Kahn, A. P. (2024). Identification of CDK4/6 Inhibitors as Small Molecule NLRP3 Inflammasome Activators that Facilitate IL-1β Secretion and T Cell Adjuvanticity. Journal of Medicinal Chemistry, 67(17), 14974–14985. https://doi.org/10.1021/acs.jmedchem.4c00516
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Knight, H. R., Ketter, E., Ung, T., Weiss, A., Jainu Ajit, Chen, Q., … Esser-Kahn, A. (2024). High-throughput screen identifies non inflammatory small molecule inducers of trained immunity. Proceedings of the National Academy of Sciences, 121(29). https://doi.org/10.1073/pnas.2400413121
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Cassaidy, B. J., Moser, B. A., Solanki, A., Chen, Q., Shen, J., Gotsis, K., … Esser, A. P. (2024). Immune Potentiation of PLGA Controlled-Release Vaccines for Improved Immunological Outcomes. ACS Omega, 9(10). https://doi.org/10.1021/acsomega.3c06552
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Ajit, J., Chen, Q., Ung, T., Rosenberger, M., Kim, J., Solanki, A., … Esser, A. P. (2024). β-glucan induced trained immunity enhances antibody levels in a vaccination model in mice. Preprint at BioRxiv. https://doi.org/10.1101/2024.04.11.588932
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Ajit, J., Knight, H. R., Chen, Q., Solanki, A., Shen, J., & Esser, A. P. (2024). Novel non-immunogenic trained immunity inducing small molecule with improved anti-tumor properties. Preprint at BioRxiv. https://doi.org/10.1101/2024.03.22.585780
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Kim, J. Y., Rosenberger, M. G., Chen, S., Ip, C. K., Bahmani, A., Chen, Q., ... & Esser-Kahn, A. P. (2023). Discovery of New States of Immunomodulation for Vaccine Adjuvants via High Throughput Screening: Expanding Innate Responses to PRRs. ACS Central Science, 9(3), 427-439. https://pubs.acs.org/doi/full/10.1021/acscentsci.2c01351
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Manna S, Maiti S, Shen J, Weiss A, Mulder E, Du W, Esser-Kahn AP. Nanovaccine that activates the NLRP3 inflammasome enhances tumor specific activation of anti-cancer immunity. Biomaterials. 2023 May 1;296:122062. https://doi.org/10.1016/j.biomaterials.2023.122062
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Ajit, J.; Cassaidy, B.; Tang, S.; Solanik, A.; Chen, Q.; Shen, J.; Esser-Kahn, A.P. Temporal control of trained immunity via encapsulated release of β-glucan improves therapeutic applications, Advanced Healthcare Materials, https://doi.org/10.1002/adhm.202200819
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Kimani, F. W.; Manna, S.; Moser, B.; Shen, J.; Nihesh, N.; Esser-Kahn, A. P. Improving the Adjuvanticity of Small Molecule Immune Potentiators Using Covalently Linked NF-ΚB Modulators. ACS Med. Chem. Lett. 2021, 12 (9), 1441–1448. https://doi.org/10.1021/acsmedchemlett.1c00267.
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Nihesh, N.; Manna, S.; Studnitzer,B.; Shen, J.; P.Esser-Kahn, A. A Synthetic Pathogen Mimetic Molecule Induces a Highly Amplified Synergistic Immune Response via Activation of Multiple Signaling Pathways. Chemical Science 2021. https://doi.org/10.1039/D1SC00964H.
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​Manna, S.; Maiti, S.; Shen, J.; Du, W.; Esser-Kahn, A. P. Pathogen-like Nanoassemblies of Covalently Linked TLR Agonists Enhance CD8 and NK Cell-Mediated Antitumor Immunity. ACS Cent. Sci.2020, 6(11), 2071–2078. https://doi.org/10.1021/acscentsci.0c01001.
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Maiti, S.; Manna, S.; Shen, J.; Esser-Kahn, A. P.; Du, W. Mitigation of Hydrophobicity-Induced Immunotoxicity by Sugar Poly(Orthoesters). J. Am. Chem. Soc.2019, 141(11), 4510–4514. https://doi.org/10.1021/jacs.8b12205.
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Manna, S.; Howitz, W. J.; Oldenhuis, N. J.; Eldredge, A. C.; Shen, J.; Nihesh, F. N.; Lodoen, M. B.; Guan, Z.; Esser-Kahn, A. P. Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture. ACS Cent. Sci. 2018, 4 (8), 982–995. https://doi.org/10.1021/acscentsci.8b00218
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Quantitative susceptibility mapping as a monitoring biomarker in cerebral cavernous malformations wi
Hussein A. Zeineddine, MD, Romuald Girard, PhD, Ying Cao, MS, Nicholas Hobson, MS, Maged D. Fam, MD, Agnieszka Stadnik, MS, Huan Tan, PhD, Jingjing Shen, MD, Kiranj Chaudagar, PhD, Robert Shenkar, PhD, Richard E. Thompson, PhD, Nichol McBee, MPH, Daniel Hanley, MD, Timothy Carroll, PhD, Gregory A. Christoforidis, MD and Issam A. Awad, MD. Quantitative susceptibility mapping as a monitoring biomarker in cerebral cavernous malformations wi. Journal of Magnetic Resonance Imaging. 2017.
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Measuring Surgical Outcomes in Subaxial Degenerative Cervical Spine Disease Patients: Minimum Clinic
Brenda Auffinger, Sandi Lam, Jingjing Shen, Ben Z. Roitberg. Measuring Surgical Outcomes in Subaxial Degenerative Cervical Spine Disease Patients: Minimum Clinic. Neurosurgery. 2014. Vol. 74, Pg. 206-214.
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The Impact of Obesity on Surgeon Ratings and Patient-Reported Outcome Measures After Degenerative Ce
Brenda Auffinger, Sandi Lam. Jennifer Kraninger, Jingjing Shen, Ben Z. Roitberg. The Impact of Obesity on Surgeon Ratings and Patient-Reported Outcome Measures After Degenerative Ce. World Neurosurgery. 2013. Vol. 82, Pg. 345-352.
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Usefulness of minimum clinically important difference for assessing patients with subaxial degenerat
Brenda Auffinger, Sandi Lam, Jingjing Shen, Bart Thaci, Ben Z. Roitberg. Usefulness of minimum clinically important difference for assessing patients with subaxial degenerat. Acta Neurochirurgica. 2013. Vol. 155, Pg. 2345–2355.
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Comparison between patient and surgeon perception of degenerative spine disease outcomes—a prospecti
Ben Z. Roitberg, Bart Thaci, Brenda Auffinger, Laura Kaplan, Jingjing Shen, Frederick D. Brown, Sandi Lam. Comparison between patient and surgeon perception of degenerative spine disease outcomes—a prospecti. Acta Neurochirurgica. 2013. Vol. 155, Pg. 757-764.
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Ethnic and geographical differences in HLA associations with the outcome of hepatitis C virus infect
Jane H Wang, Xin Zheng, Xiaogang Ke, M Tevfik Dorak, Jingjing Shen, Basmattee Boodram, Maurice O'Gorman, Kenneth Beaman, Scott J Cotler, Ronald Hershow and Lijun Rong. Ethnic and geographical differences in HLA associations with the outcome of hepatitis C virus infect. Virology Journal. 2009. Vol. 6.
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The role of HLA-DRB1*07 and Cw*0602 in development of psoriasis in Chinese patients.
Shen Jingjing, Yang Ze, Tang Lei, Sun Yiping.. The role of HLA-DRB1*07 and Cw*0602 in development of psoriasis in Chinese patients.. Journal of Clinical Dermatology. 2001. Vol. 30, Pg. 103-116.